Talk Session: SESSION 10: NEW HORIZONS IN PEPTIDE SCIENCE: GREEN METHODS AND DATA SCIENCE
Date: Wednesday, June 15, 2022
Talk Time: 08:00 am - 08:25 am
Talk Title: Expanded Molecular Access with Enhanced Efficiency in Microwave-Assisted Solid-Phase Peptide Synthesis
2021 - present, Director of Scientific Acceleration, CEM; 2020 - 2021, Senior Medical Science Liaison, Amgen, USA; 2018 – 2020, Medical Science Liaison, Allergan, USA; 2015 – 2018, Scientist II, Ferring Pharmaceuticals, USA; 2012 – 2015, Applications Specialist, Biotage, Americas
2010 – 2012, Postdoctoral Fellow with Robert Hodges, University of Colorado Health Sciences Center; 2005 – 2010, Ph.D. Medicinal Chemistry with Jane Aldrich, University of Kansas; 2003 – 2005, M.S. Pharmaceutical Sciences with David Segal, University of Arizona; 1997 – 2001, B.S. Chemistry and Zoology, Northern Arizona University
My deep dive into peptide science began with an opportunity to join the laboratory of former APS President Dr. Jane V. Aldrich. It was during my tenure as a graduate student in Jane’s lab when I had my first exposure to APS, the 2007 meeting in Montreal, Québec. The remarkable presentations and scientific discussions were inspiring. I was then and remain now, moved by the welcoming nature of the peptide community. Since that meeting, I have taken numerous opportunities to participate in the symposium and the society.
It has been exhilarating to work with students and professionals on SAC both as a student and as a professional. Helping to raise funds for the symposium, a worthwhile but hefty task, has brought me closer to our members across so many different areas of research, backgrounds, and segments.
Promoting the value of membership in our community is my passion. I am seeking the role of councilor to further immerse myself in the society and drive continued exploration of value and member engagement.
The ability to drive molecular innovation in medicine and technology is powered by the methods and techniques to move from conception to reality. Here, we present three case studies that demonstrate the power of technology to expand molecular access.
Case Study 1: Rapid production of neoantigens for personalized treatment of cancer
Case Study 2: Chemical synthesis of 100-mer peptides and proteins in under 24 h
Case Study 3: Microwave-Assisted SPPS to expedite the production of peptides at the kilogram scale
These case studies reveal that when engineering and chemistry are optimized together, high-throughput SPPS, long peptide/short protein synthesis, and kilogram production of peptides can be compatible with improved efficiency and the greening of peptide science.