SUNY at Albany
Talk Session: SESSION 4: SYNTHETIC METHODOLOGY FOR PEPTIDE AND PROTEIN SYNTHESIS
Date: Monday, June 13, 2022
Talk Time: 08:00 am - 08:25 am
Talk Title: Studies toward Protein Conjugation via Reversible Covalent Sigma Bonds
Our research group's primary interests include novel chemical methodology facilitated polypeptide; carbohydrate, and glycoprotein synthesis. We are also focusing on the phenolic dearomatization strategy development towards important therapeutic and material evaluations.
The site-selective conjugation of a native peptide or protein is arguably the most efficient technologies to functionalize biologics. Although the biological approaches such as enzymatically amend proteins demonstrate high selectivity and capacity. Utilization of sophisticate cell machinery system prevent biological method from rapid, large scale production of modified proteins. Chemical approaches are naturally attractive attribute to their low operational cost and simpler system, yet often suffer from poor chemoselectivity. The development of chemical technology that allows site-specific functionalization of a native protein is critical.
We report the synthetic methodologies that achieve chemoselective activation of a peptide or protein C-terminus or N-terminus, which enables subsequent head to tail cyclization to provide cyclic peptide and proteins under physiological conditions. Realize controllable, site-specifically protein bioconjugation at N-termini in a reversible manner.